Rat Two-generation Reproductive Toxicity
The objective of this test is to obtain information on the reproductive toxicity of a test substance. In this test, a test substance is administered to test animals over two generations successively and reproductive toxicity is examined in a comprehensive manner through a series of tests in which the test substance is administered at the pre-conception period and initial stage of pregnancy, fetus development stage, prenatal period and lactation. In recent years this test has come to be one of the most highly regarded in Europe and the Americas.